Prediction of function changes associated with single-point protein mutations using support vector machines (SVMs)
نویسندگان
چکیده
منابع مشابه
Prediction of function changes associated with single-point protein mutations using support vector machines (SVMs).
Computational methods can be used to predict the effects of single amino acid substitutions (single-point mutations). In contrast to previous methods that need many protein sequence and structural features, we applied support vector machines (SVMs) to predict protein function changes associated with amino acid substitutions using only sequence information, and cross-validated them on a large da...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2009
ISSN: 1059-7794,1098-1004
DOI: 10.1002/humu.21039